BDBM50630207 CHEMBL5422933::US12247029, Entry 1

SMILES Oc1cccc(c1)-c1csc(NC(=O)CSc2nc3nccnc3c(=O)n2CCc2ccccc2)n1

InChI Key InChIKey=KPWZZHNCABTUGN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50630207   

LigandPNGBDBM50630207(CHEMBL5422933 | US12247029, Entry 1)
Affinity DataIC50: 200nMAssay Description:Inhibition of PI3KC2alpha deltaN domain (unknown origin) preincubated for 5 mins followed by substrate addition and measured after 20 mins in the pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630207(CHEMBL5422933 | US12247029, Entry 1)
Affinity DataIC50: 121nMAssay Description:Inhibition of recombinant GST-tagged human PI3KC2alpha (142 to 1412 residues) expressed in baculovirus expression system using PI lipid kinase as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630207(CHEMBL5422933 | US12247029, Entry 1)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of PI3KC2beta (unknown origin) using PI lipid kinase as substrate in the presence of 10 uM ATP by Adapta universal kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630207(CHEMBL5422933 | US12247029, Entry 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3KC2gamma (unknown origin) in the presence of 10 uM ATP by Adapta universal kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630207(CHEMBL5422933 | US12247029, Entry 1)
Affinity DataIC50: 120nMAssay Description:ADP-Glo kinase assay was performed as described by the manufacturer's protocol. Briefly, the kinase assay was performed with a 5 mixture of liver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2025
Entry Details
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