BDBM50630171 CHEMBL5400057::US12247029, Entry 11

SMILES c1ccc(cc1)CCN2C(=O)c3c(nccn3)N=C2SCC(=O)Nc4nccs4

InChI Key InChIKey=ANHMCIKPOJARRV-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50630171   

LigandPNGBDBM50630171(CHEMBL5400057 | US12247029, Entry 11)
Affinity DataIC50: 100nMAssay Description:Inhibition of PI3KC2alpha deltaN domain (unknown origin) preincubated for 5 mins followed by substrate addition and measured after 20 mins in the pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50630171(CHEMBL5400057 | US12247029, Entry 11)
Affinity DataIC50: 5.71E+3nMAssay Description:Inhibition of PI3KC2beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630171(CHEMBL5400057 | US12247029, Entry 11)
Affinity DataIC50: 95nMAssay Description:Inhibition of recombinant GST-tagged human PI3KC2alpha (142 to 1412 residues) expressed in baculovirus expression system using PI lipid kinase as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50630171(CHEMBL5400057 | US12247029, Entry 11)
Affinity DataIC50: 5.71E+3nMAssay Description:Inhibition of PI3KC2beta (unknown origin) using PI lipid kinase as substrate in the presence of 10 uM ATP by Adapta universal kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630171(CHEMBL5400057 | US12247029, Entry 11)
Affinity DataIC50: 858nMAssay Description:Inhibition of PI3KC2gamma (unknown origin) in the presence of 10 uM ATP by Adapta universal kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630171(CHEMBL5400057 | US12247029, Entry 11)
Affinity DataIC50: 100nMAssay Description:ADP-Glo kinase assay was performed as described by the manufacturer's protocol. Briefly, the kinase assay was performed with a 5 mixture of liver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)