BDBM50621798 CHEMBL5403208
SMILES O=c1cc(oc2ccccc12)-c1ccc(OCCOCCNCc2ccccc2)cc1
InChI Key InChIKey=JIFJFNBTQSCGBM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 30 hits for monomerid = 50621798
Affinity DataIC50: 11nMAssay Description:Negative allosteric modulator activity at human P-gp Q1193N mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 6.90nMAssay Description:Negative allosteric modulator activity at human P-gp T1226F mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 7.20nMAssay Description:Negative allosteric modulator activity at human P-gp T1226Y mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 6.40nMAssay Description:Negative allosteric modulator activity at human P-gp T1226W mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 10nMAssay Description:Negative allosteric modulator activity at human P-gp I1115L mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 43nMAssay Description:Negative allosteric modulator activity at human P-gp I1115F mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 7.90nMAssay Description:Negative allosteric modulator activity at human P-gp I1115M mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 9.90nMAssay Description:Negative allosteric modulator activity at human P-gp I1115N mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 7.60nMAssay Description:Negative allosteric modulator activity at human P-gp I1115E mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 7.80nMAssay Description:Negative allosteric modulator activity at human P-gp I1115K mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 8.20nMAssay Description:Negative allosteric modulator activity at human P-gp I1115Y mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 8.30nMAssay Description:Negative allosteric modulator activity at human P-gp I1115W mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 4.80nMAssay Description:Negative allosteric modulator activity at human P-gp G1114L mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 8.60nMAssay Description:Negative allosteric modulator activity at human P-gp G1114I mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 3.5nMAssay Description:Negative allosteric modulator activity at human P-gp G1114V mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 3.80nMAssay Description:Negative allosteric modulator activity at P-gp in human LCC6MDR cells overexpressing P-gp assessed as reversal of P-gp mediated PTX resistance by mea...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 61nMAssay Description:Negative allosteric modulator activity at human P-gp Q1193T mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 29nMAssay Description:Negative allosteric modulator activity at human P-gp Q1193C mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 48nMAssay Description:Negative allosteric modulator activity at human P-gp Q1193K mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 93nMAssay Description:Negative allosteric modulator activity at human P-gp Q1193E mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 81nMAssay Description:Negative allosteric modulator activity at human P-gp Q1193F mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 5.20nMAssay Description:Negative allosteric modulator activity at human P-gp C1227A mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 4.20nMAssay Description:Negative allosteric modulator activity at human P-gp L1113A mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 112nMAssay Description:Negative allosteric modulator activity at human P-gp Q1193A mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 4.60nMAssay Description:Negative allosteric modulator activity at human P-gp T1226A mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 4.70nMAssay Description:Negative allosteric modulator activity at human P-gp H1195A mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 6.30nMAssay Description:Negative allosteric modulator activity at human P-gp I1115A mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 7.40nMAssay Description:Negative allosteric modulator activity at human wildtype P-gp expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance by mea...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 4.30nMAssay Description:Negative allosteric modulator activity at human P-gp G1114A mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataEC50: 83nMAssay Description:Negative allosteric modulator activity at P-gp in human LCC6MDR cells overexpressing P-gp assessed as reversal of P-gp mediated paclitaxel resistance...More data for this Ligand-Target Pair
Ligand InfoSimilars