BDBM50597920 CHEMBL5180041

SMILES Oc1cccc(NC(=O)Cc2ccc3cc[nH]c3c2)c1

InChI Key InChIKey=UOBOMCZZCHPHBU-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50597920   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50597920(CHEMBL5180041)
Affinity DataIC50: 77nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS/nigericin-stimulated PMA-differentiated human THP-1 macrophages assessed as reduction in pyroptosi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50597920(CHEMBL5180041)
Affinity DataIC50: 98nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed human THP-1 cells assessed as reduction in IL-1beta release in supernatant pretreated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50597920(CHEMBL5180041)
Affinity DataIC50: 58nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed human THP-1 cells assessed as reduction in IL-18 release in supernatant pretreated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50597920(CHEMBL5180041)
Affinity DataKd:  1.63E+6nMAssay Description:Binding affinity to recombinant human full length NLRP3 expressed in Sf9 insect cells assessed as dissociation constant incubated for 30 mins by MST ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50597920(CHEMBL5180041)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed C57BL/6 mouse BMDMs assessed as suppression of nigericin induced IL-1beta release preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50597920(CHEMBL5180041)
Affinity DataIC50: 1.96E+4nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 assessed as suppression of nigericin induced IL-1beta release preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed