BDBM50596729 CHEMBL5189473::US20230348421, Compound 82

SMILES CN1CCC(CC1)N(Cc1ccc(F)cn1)C(=O)NCc1ccc(OCCCC(F)(F)F)cc1

InChI Key InChIKey=MZXDTNDATCLJJR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50596729   

Target5-hydroxytryptamine receptor 2A(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50596729(CHEMBL5189473 | US20230348421, Compound 82)
Affinity DataIC50: 3.80nMAssay Description:Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50596729(CHEMBL5189473 | US20230348421, Compound 82)
Affinity DataIC50: 2nMAssay Description:Inverse agonist activity at 5-HT2A receptor (unknown origin) expressed in mouse NIH3T3 cells using o-nitrophenyl-D-galacto pyranoside incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50596729(CHEMBL5189473 | US20230348421, Compound 82)
Affinity DataIC50: 3.78nMAssay Description:CHO-K1/5-HT2A cells in the logarithmic growth phase were seeded into a 384-well plate at a density of 10000 cells per well, and cultured in a 37° C.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50596729(CHEMBL5189473 | US20230348421, Compound 82)
Affinity DataIC50: 1.95nMAssay Description:NIH3T3-5HT2AR cells in the logarithmic growth phase were seeded into a white-wall clear-bottom 96-well plate at a density of 1000 cells per well, and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Geneora Pharma (Shijiazhuang) Co.

US Patent
LigandPNGBDBM50596729(CHEMBL5189473 | US20230348421, Compound 82)
Affinity DataIC50: 500nMAssay Description:CHO (Chinese Hamster Ovary) cells stably expressing hERG potassium channels were taken, and hERG potassium channel currents were recorded at room tem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent