BDBM50579593 CHEMBL4860030::US12195473, Amgen 6.3

SMILES CC(C)c1ncnc(C(C)C)c1-n1c2nc(c(Cl)cc2c(N2CCN(CC2)C(=O)C=C)c(C#N)c1=O)-c1c(N)cccc1F

InChI Key InChIKey=QHUBNSPYEJDRRB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50579593   

TargetGTPase KRas(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50579593(CHEMBL4860030 | US12195473, Amgen 6.3)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of GDP-loaded His-tagged KRAS G12C mutant (2 to 182 residues) (unknown origin) assessed as inhibition of SOS1-catalyzed nucleotide exchang...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50579593(CHEMBL4860030 | US12195473, Amgen 6.3)
Affinity DataIC50: 20nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2022
Entry Details Article
PubMed
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM50579593(CHEMBL4860030 | US12195473, Amgen 6.3)
Affinity DataIC50: 2.77nMAssay Description:HIS-KRAS (G12C, aa 2-185, Sino biological) was diluted to 5 μM in EDTA buffer (20 mM HEPES, pH 7.4, 50 mM NaCl, 10 mM EDTA, 0.01% (v/v) Tween-20) and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent