BDBM50568503 CHEMBL4876427::US12083137, Compound 28

SMILES [#6]-[#6]C([#6]-c1cn(-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])nn1)(P([#8-])([#8-])=O)P([#8-])([#8-])=O

InChI Key InChIKey=LPVCRWPSKPNXIZ-UHFFFAOYSA-J

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50568503   

TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Iowa

Curated by ChEMBL
LigandPNGBDBM50568503(CHEMBL4876427 | US12083137, Compound 28)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of recombinant GGDPS (unknown origin) using FPP and [14C] IPP as substrate preincubated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Iowa

Curated by ChEMBL
LigandPNGBDBM50568503(CHEMBL4876427 | US12083137, Compound 28)
Affinity DataIC50: 5.85E+3nMAssay Description:Recombinant GGDPS was obtained from MyBioSource (San Diego, CA). Recombinant enzyme (20 nM GGDPS) was incubated with assay buffer (50 mM Tris-HCl, pH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2025
Entry Details
Go to US Patent

TargetFarnesyl pyrophosphate synthase(Human)
University of Nebraska

US Patent
LigandPNGBDBM50568503(CHEMBL4876427 | US12083137, Compound 28)
Affinity DataIC50: 9.43E+4nMAssay Description:Recombinant GGDPS was obtained from MyBioSource (San Diego, CA). Recombinant enzyme (20 nM GGDPS) was incubated with assay buffer (50 mM Tris-HCl, pH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2025
Entry Details
Go to US Patent