BDBM50567180 CHEMBL4847146

SMILES Cc1cccc2cccc(N3CCc4c(C3)nc(cc4N3CCN([C@@H](CC#N)C3)C(=O)C=C)C(=O)NC3(C)CCCNC3)c12

InChI Key InChIKey=VEUVZMZIFQJIDK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50567180   

TargetGTPase KRas(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50567180(CHEMBL4847146)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of biotinylated KRAS G12C mutant (unknown origin) assessed as inhibition of SOS-catalyzed nucleotide exchange preincubated for 60 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed