BDBM50567179 CHEMBL4860377

SMILES CCC1(CCNC1)NC(=O)c1cc(N2CCN([C@@H](CC#N)C2)C(=O)C=C)c2CCN(Cc2n1)c1cccc2cccc(C)c12

InChI Key InChIKey=CEJMDPIUVBSTPO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50567179   

TargetGTPase KRas(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50567179(CHEMBL4860377)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of biotinylated KRAS G12C mutant (unknown origin) assessed as inhibition of SOS-catalyzed nucleotide exchange preincubated for 60 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed