BDBM50553944 CHEMBL4780624

SMILES CCOC(=O)[C@@H](Cc1ncccn1)NC(=O)Nc1c2CCCc2cc2CCCc12

InChI Key InChIKey=DGKQGJVFBMUMLC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50553944   

LigandPNGBDBM50553944(CHEMBL4780624)
Affinity DataIC50: 36nMAssay Description:Inhibition of NLRP3 in human PBMC cells assessed as inhibition of LPS and ATP-induced IL-1beta productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50553944(CHEMBL4780624)
Affinity DataIC50: 160nMAssay Description:Inhibition of NLRP3 in human whole blood assessed as inhibition of LPS and ATP-induced IL-1beta productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50553944(CHEMBL4780624)
Affinity DataIC50: 33nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in nigercin-induced ASC speck formation measuring green fluorescent protein aggregatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50553944(CHEMBL4780624)
Affinity DataIC50: 36nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-activated human PBMC cells assessed as inhibition of ATP/nigericin induced IL-1beta secretion prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50553944(CHEMBL4780624)
Affinity DataIC50: 160nMAssay Description:Inhibition of NLRP3 inflammasome activation in human whole blood assessed as inhibition of LPS/ATP induced IL-1beta secretion preincubated with LPS f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50553944(CHEMBL4780624)
Affinity DataIC50: 33nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-induced human THP-1 cells expressing GFP-tagged ASC assessed as disruption of ASC speck formation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed