BDBM50546231 CHEMBL4746515

SMILES OS(=O)(=O)c1ccc(N\N=C2/C(=O)N(N=C2c2ccc(cc2)[N+]([O-])=O)c2ccc(Cl)cc2)cc1

InChI Key InChIKey=ZHQLSYWPGHMSAJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50546231   

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50546231(CHEMBL4746515)
Affinity DataIC50: 8.93E+3nMAssay Description:Inhibition of PTP1B (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50546231(CHEMBL4746515)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of N-terminal His6-tagged TEV cleavage site-fused human SHP2 catalytic domain (248 to 527 residues) expressed in Escherichia coli Rosetta(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50546231(CHEMBL4746515)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of SHP1 (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed