BDBM50529018 CHEMBL4553096

SMILES [H][C@@]1(COC(=O)N1c1ccnc(N[C@@H](C)c2ncn-3c2CCc2c(Cl)cccc-32)n1)[C@H](C)F

InChI Key InChIKey=MGDNIHFSZHBKLT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50529018   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50529018(CHEMBL4553096)
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human C-terminal His8-tagged IDH1 R132H mutant expressed in Escherichia coli BL21 assessed as reduction in NADPH consumptio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50529018(CHEMBL4553096)
Affinity DataIC50: 82nMAssay Description:Inhibition of recombinant human C-terminal His8-tagged IDH1 R132C mutant expressed in Escherichia coli BL21 assessed as reduction in NADPH consumptio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed