BDBM50519889 CHEMBL4466846

SMILES CC(C)(C)OC(=O)c1ccc(NC(=O)c2c(noc2-c2ccccc2)-c2c(Cl)cccc2C(F)(F)F)cc1

InChI Key InChIKey=QKYNQIMGGOSFRD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50519889   

TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50519889(CHEMBL4466846)
Affinity DataIC50: 1.00E+5nMAssay Description:Inverse agonist activity at human N-terminal His6-tagged RORgammat LBD (265 to 518 residues) expressed in Escherichia coli BL21 (DE3) assessed as inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50519889(CHEMBL4466846)
Affinity DataIC50: 5.00E+4nMAssay Description:Inverse agonist activity at His6-tagged PPARgamma LBD (unknown origin) assessed as inhibition of rosiglitazone-induced N-terminal biotinylated co-act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed