BDBM50517183 CHEMBL4577812

SMILES Brc1ccc(OCC(=O)NC2CN(C2)C(=O)C=C)c(c1)C(=O)N1CC=C(C1)c1ccccc1

InChI Key InChIKey=FFGUVJHQGPXURJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50517183   

TargetGTPase KRas(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50517183(CHEMBL4577812)
Affinity DataIC50: 2.78E+3nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50517183(CHEMBL4577812)
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed