BDBM50465552 CHEMBL4291641::US10501466, Example B29

SMILES COc1cc(cc(OC)c1C)C(=O)N[C@@H]1CCc2ccc(cc12)-c1cn2CCCc2n1

InChI Key InChIKey=GRFBFSARRYJWSN-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50465552   

TargetWD repeat-containing protein 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50465552(CHEMBL4291641 | US10501466, Example B29)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human WDR5 (22 to 334 residues) assessed as reduction in WRAD-mediated human MLL1 ( 3745 to 3969 residues) H3K4 methylation using human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetWD repeat-containing protein 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50465552(CHEMBL4291641 | US10501466, Example B29)
Affinity DataKi:  0.902nMAssay Description:Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetWD repeat-containing protein 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50465552(CHEMBL4291641 | US10501466, Example B29)
Affinity DataKi:  0.902nMAssay Description:A fluorescence polarization anisotropy (FPA) assay that measures the displacement of either a FITC-labeled MLL-derived peptide or a more potent 10mer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetWD repeat-containing protein 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50465552(CHEMBL4291641 | US10501466, Example B29)
Affinity DataKi: <1nMAssay Description:Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed