BDBM50452818 CHEMBL4204500::US12083137, Compound 19

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]-[#6](-[#6])=[#6]-[#6]-n1cc(-[#6]C([#6])(P([#8-])([#8-])=O)P([#8-])([#8-])=O)nn1

InChI Key InChIKey=MRSKAUJQUGOYPS-UHFFFAOYSA-J

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50452818   

TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Iowa

Curated by ChEMBL
LigandPNGBDBM50452818(CHEMBL4204500 | US12083137, Compound 19)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of recombinant GGDPS (unknown origin) using FPP as substrate pretreated for 10 mins followed by substrate addition measured after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Iowa

Curated by ChEMBL
LigandPNGBDBM50452818(CHEMBL4204500 | US12083137, Compound 19)
Affinity DataIC50: 6.22E+4nMAssay Description:Inhibition of recombinant FDPS (unknown origin) using GPP as substrate pretreated for 10 mins followed by substrate addition measured after 30 mins i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Iowa

Curated by ChEMBL
LigandPNGBDBM50452818(CHEMBL4204500 | US12083137, Compound 19)
Affinity DataIC50: 100nMAssay Description:Recombinant GGDPS was obtained from MyBioSource (San Diego, CA). Recombinant enzyme (20 nM GGDPS) was incubated with assay buffer (50 mM Tris-HCl, pH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2025
Entry Details
Go to US Patent

TargetFarnesyl pyrophosphate synthase(Human)
University of Iowa

Curated by ChEMBL
LigandPNGBDBM50452818(CHEMBL4204500 | US12083137, Compound 19)
Affinity DataIC50: 2.41E+4nMAssay Description:Recombinant GGDPS was obtained from MyBioSource (San Diego, CA). Recombinant enzyme (20 nM GGDPS) was incubated with assay buffer (50 mM Tris-HCl, pH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2025
Entry Details
Go to US Patent