BDBM50422748 CHEMBL5269280::US20250084039, Compound HSN286

SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3c(N)ncc4ccc(Cl)cc34)cc2C(F)(F)F)CC1

InChI Key InChIKey=HRNNGONZVJUBCF-UHFFFAOYSA-N

Data  2 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50422748   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422748(CHEMBL5269280 | US20250084039, Compound HSN286)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of FLT3-ITD mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422748(CHEMBL5269280 | US20250084039, Compound HSN286)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50422748(CHEMBL5269280 | US20250084039, Compound HSN286)
Affinity DataKd:  6nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50422748(CHEMBL5269280 | US20250084039, Compound HSN286)
Affinity DataKd:  27.6nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835V](Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50422748(CHEMBL5269280 | US20250084039, Compound HSN286)
Affinity DataKd:  120nMAssay Description:Table 8: The binding of HSN286, HSN336, HSN334, HSN248 and HSN247 with several FLT3 secondary mutations (Table 8) was investigated. Interestingly, HS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50422748(CHEMBL5269280 | US20250084039, Compound HSN286)
Affinity DataKd:  26nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [F691L](Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50422748(CHEMBL5269280 | US20250084039, Compound HSN286)
Affinity DataKd:  110nMAssay Description:Table 10: IC50 values for the inhibition of FLT3 kinase enzymatic activity by midostaurin, HSN286, 334 and 356 were determined. All of the four compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2025
Entry Details
Go to US Patent