BDBM50347982 CHEMBL1800159::US20250000864, Compound Relugolix

SMILES CONC(=O)Nc1ccc(cc1)-c1sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccc(OC)nn3)c(=O)c2c1CN(C)C

InChI Key InChIKey=AOMXMOCNKJTRQP-UHFFFAOYSA-N

Data  9 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50347982   

TargetGonadotropin-releasing hormone receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347982(CHEMBL1800159 | US20250000864, Compound Relugolix)
Affinity DataIC50: 0.820nMAssay Description:Antagonist activity at human GnRH receptor expressed in CHO cells assessed as inhibition of GnRH-induced arachidonic acid release using [5,6,8,9,11,1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347982(CHEMBL1800159 | US20250000864, Compound Relugolix)
Affinity DataIC50: 0.320nMAssay Description:Displacement of [125I]leuprorelin from rat GnRH receptor expressed in CHO cells after 60 mins by X-ray counter in presence of 40% fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347982(CHEMBL1800159 | US20250000864, Compound Relugolix)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human GnRH receptor expressed in CHO cells assessed as inhibition of GnRH-induced arachidonic acid release using [5,6,8,9,11,1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347982(CHEMBL1800159 | US20250000864, Compound Relugolix)
Affinity DataIC50: 0.320nMAssay Description:Displacement of [125I]leuprorelin from rat GnRH receptor expressed in CHO cells after 60 mins by X-ray counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347982(CHEMBL1800159 | US20250000864, Compound Relugolix)
Affinity DataIC50: 0.330nMAssay Description:Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counter in presence of 40% fetal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347982(CHEMBL1800159 | US20250000864, Compound Relugolix)
Affinity DataIC50: 0.330nMAssay Description:Antagonist activity at human GnRH receptor expressed in CHO cells assessed as inhibition of GnRH-induced arachidonic acid release using [5,6,8,9,11,1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347982(CHEMBL1800159 | US20250000864, Compound Relugolix)
Affinity DataIC50: 0.0800nMAssay Description:Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347982(CHEMBL1800159 | US20250000864, Compound Relugolix)
Affinity DataKd:  0.372nMAssay Description:Inhibition of Tag-lite green-labeled agonist binding to terbium fluorophore-labeled human N-terminal SNAP-tag GnRh receptor expressed in HEK293 cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347982(CHEMBL1800159 | US20250000864, Compound Relugolix)
Affinity DataKd:  0.840nMAssay Description:Inhibition of Tag-lite green-labeled agonist binding to terbium fluorophore-labeled human N-terminal SNAP-tag GnRh receptor expressed in HEK293 cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347982(CHEMBL1800159 | US20250000864, Compound Relugolix)
Affinity DataIC50: 0.25nMAssay Description:Displacement of [1251][D-Trp6]-LH-RH from human GnRH-R expressed in Chem-1 cells incubated for 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347982(CHEMBL1800159 | US20250000864, Compound Relugolix)
Affinity DataIC50: 0.25nMAssay Description:Equipment: MicroBeta2 LumiJET system, PerkinElmer. Method: Chem-1 cell membranes stably expressing human GnRHR were resuspended in HEPES at pH 7.4. 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2025
Entry Details
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