BDBM50287566 CHEMBL4160797::US11572354, Compound 10m

SMILES Oc1ccc(Cl)cc1-c1cncn1Cc1cc2cc(F)ccc2[nH]1

InChI Key InChIKey=VHSVJUKMYOSUKL-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50287566   

TargetTryptophan 2,3-dioxygenase(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287566(CHEMBL4160797 | US11572354, Compound 10m)
Affinity DataIC50: 5.44E+4nMAssay Description:Inhibition of recombinant human 6His-tagged TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in kynurenine production using L-tryp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287566(CHEMBL4160797 | US11572354, Compound 10m)
Affinity DataEC50:  260nMAssay Description:Inhibition of recombinant human IDO1 assessed as reduction in kynurenine production using L-tryptophan as substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287566(CHEMBL4160797 | US11572354, Compound 10m)
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant human IDO1 assessed as reduction in kynurenine production using L-tryptophan as substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287566(CHEMBL4160797 | US11572354, Compound 10m)
Affinity DataIC50: 34nMAssay Description:A standard reaction mixture (200uL/well) containing 50mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH), 200 ug/mL ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
Go to US Patent

TargetTryptophan 2,3-dioxygenase(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287566(CHEMBL4160797 | US11572354, Compound 10m)
Affinity DataIC50: 5.44E+4nMAssay Description:A Standard reaction mixture (200 uL/well) containing 50 mM potassium phosphate buffer (pH 6.5), 20mM ascorbic acid (neutralized with NaOH), 200 ug/ml...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
Go to US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50287566(CHEMBL4160797 | US11572354, Compound 10m)
Affinity DataIC50: 34nMAssay Description:Inhibition of human IDO1 using L-tryptophan as substrate assessed as reduction in N-formyl kynurenine formation by UV-visible spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed