BDBM50259682 CHEMBL4082527

SMILES Cc1cc(Nc2ccc(F)cc2)n2nc(SCc3nc4ccccc4[nH]3)nc2n1

InChI Key InChIKey=ZGRDQSSNSDLZLJ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50259682   

TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50259682(CHEMBL4082527)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human LSD1 (157 to 852 residues) expressed in Escherichia coli BL21(DE3) using H3K4me2 as substrate preincubated for 1 hr f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50259682(CHEMBL4082527)
Affinity DataIC50: 5nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50259682(CHEMBL4082527)
Affinity DataIC50: 10nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50259682(CHEMBL4082527)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human KB-C2 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50259682(CHEMBL4082527)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50259682(CHEMBL4082527)
Affinity DataIC50: 7.36E+4nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50259682(CHEMBL4082527)
Affinity DataIC50: 22nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50259682(CHEMBL4082527)
Affinity DataIC50: 22nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human KB-C2 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed