BDBM50246866 CHEMBL4078458::US11505523, Compound 22d

SMILES COc1ccc(\C=C\C(=O)NO)c(c1)-c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=ASHPRZYGCOMVHO-UHFFFAOYSA-N

Data  26 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50246866   

TargetHistone deacetylase 6(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC6 (unknown origin) using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 27.2nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetPolyamine deacetylase HDAC10(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 4(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 3nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 20nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 3nMAssay Description:Further provided herein are methods of inhibiting HDAC8 mediated deacetylation of p53. In one aspect, the method includes contacting HDAC8 with a HDA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 27nMAssay Description:Inhibition of HDAC8 (unknown origin) (1 to 377 residues) expressed in Escherichia coli BL21(DE3) cells using Boc-Lys(TFA)-AMC as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC11 (unknown origin) using p53 (379 to 382 residues) (Arg-His-Lys-Lys(Ac)) as substrate incubated for 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC10 (unknown origin) using p53 (379 to 382 residues) (Arg-His-Lys-Lys(Ac)) as substrate incubated for 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC4 (unknown origin) (648 to 1057 residues) expressed in Escherichia coli BL21(DE3) cells using Boc-Lys(TFA)-AMC as substrate preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 27nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of HDAC3/NCoR2 (unknown origin) using p53 (379 to 382 residues) (Arg-His-Lys-Lys(Ac)) as substrate incubated for 30 mins by fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC2 (unknown origin) using p53 (379 to 382 residues) (Arg-His-Lys-Lys(Ac)) as substrate incubated for 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using p53 (379 to 382 residues) (Arg-His-Lys-Lys(Ac)) as substrate incubated for 30 mins by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant HDAC8 using H2N-Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate after 90 mins by fluorescence based micro plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 27nMAssay Description:Inhibition of human HDAC8 (1 to 377 residues) expressed in Escherichia coli BL21(DE3) using Boc-Lys(TFA)-AMC as substrate preincubated for 5 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human N-terminal GST-tagged/C-terminal His-tagged HDAC4 (627 to 1084 residues) expressed in baculovirus infected Sf9 insect cells by fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
City of Hope

US Patent
LigandPNGBDBM50246866(CHEMBL4078458 | US11505523, Compound 22d)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed