BDBM50235052 CHEMBL4099688

SMILES COc1ccc(N2CCOCC2)c2sc(NC(=O)C3(C)CCC(O)CC3)nc12

InChI Key InChIKey=WIOZSWXTSYAXRC-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50235052   

TargetAdenosine receptor A2a(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50235052(CHEMBL4099688)
Affinity DataKi:  1.10nMAssay Description:Antagonist activity at human adenosine A2A receptor expressed in HEK293 cell membranes assessed as decrease in CGS-21680/forskolin-induced cAMP level...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50235052(CHEMBL4099688)
Affinity DataKi:  1.10nMAssay Description:Antagonist activity at recombinant human adenosine A2A receptor expressed in HEK293 cells measured by cAMP functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2a(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50235052(CHEMBL4099688)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cell membranes measured after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50235052(CHEMBL4099688)
Affinity DataKi:  5.90nMAssay Description:Binding affinity to human adenosine A2A receptor expressed in HEK293 cells measured by radioligand based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAdenosine receptor A2b(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50235052(CHEMBL4099688)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]-MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes measured after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50235052(CHEMBL4099688)
Affinity DataKi:  42nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in HEK293 cell membranes assessed as decrease in CPA/forskolin-induced cAMP level pretre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50235052(CHEMBL4099688)
Affinity DataKi:  90nMAssay Description:Displacement of [3H]-DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes measured after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50235052(CHEMBL4099688)
Affinity DataKi:  1.00E+3nMAssay Description:Antagonist activity at human adenosine A2B receptor expressed in HEK293 cell membranes assessed as decrease in NECA/forskolin-induced cAMP level pret...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2019
Entry Details Article
PubMed