BDBM50233437 CHEMBL4065147

SMILES c1cn(c2c1cc(c(c2)Cl)Cl)CCCCCNC(=O)CS

InChI Key InChIKey=MHKHGVSRGWQPII-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50233437   

TargetHistone deacetylase 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50233437(CHEMBL4065147)
Affinity DataIC50: 7.49E+3nMAssay Description:Inhibition of human HDAC1 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2019
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50233437(CHEMBL4065147)
Affinity DataIC50: 11nMAssay Description:Inhibition of human HDAC6 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2019
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50233437(CHEMBL4065147)
Affinity DataIC50: 50nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged HDAC6 (1 to 1215 residues) expressed in HEK293 cells preincubated for 15 mins followed by acet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50233437(CHEMBL4065147)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged HDAC8 (1 to 377 residues) expressed in HEK293 cells preincubated for 15 mins followed by Boc-[...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50233437(CHEMBL4065147)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50233437(CHEMBL4065147)
Affinity DataIC50: 11nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50233437(CHEMBL4065147)
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50233437(CHEMBL4065147)
Affinity DataIC50: 7.49E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50233437(CHEMBL4065147)
Affinity DataIC50: 11nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed