BDBM50221566 4-chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenol::4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenol::CHEMBL400402::US8481536, 449::US8481536, 597

SMILES Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12)-c1cc(O)ccc1Cl

InChI Key InChIKey=AQSSMEORRLJZLU-UHFFFAOYSA-N

Data  2 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50221566   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50221566(CHEMBL400402 | US8481536, 597 | US8481536, 449 | 4...)
Affinity DataIC50: 1.60nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
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TargetTyrosine-protein kinase Yes(Human)
Targegen

US Patent
LigandPNGBDBM50221566(CHEMBL400402 | US8481536, 597 | US8481536, 449 | 4...)
Affinity DataIC50: 0.5nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Targegen

US Patent
LigandPNGBDBM50221566(CHEMBL400402 | US8481536, 597 | US8481536, 449 | 4...)
Affinity DataIC50: 1.10nMAssay Description:Pdgfrβ (0.16 ug/well, Panvera/Invitrogen) 500 nM ATP and the PTK2 peptide (700 uM) were combined with compound and reaction buffer as noted abov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
Go to US Patent

TargetEphrin type-B receptor 4(Human)
Targegen

US Patent
LigandPNGBDBM50221566(CHEMBL400402 | US8481536, 597 | US8481536, 449 | 4...)
Affinity DataIC50: 15.9nMT: 2°CAssay Description:EphB4 kinase activity was similarly measured, using the luciferase-based technique described above. 28.9 mU/well EphB4 (Upstate) was reacted with 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
Go to US Patent

LigandPNGBDBM50221566(CHEMBL400402 | US8481536, 597 | US8481536, 449 | 4...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

US Patent
LigandPNGBDBM50221566(CHEMBL400402 | US8481536, 597 | US8481536, 449 | 4...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50221566(CHEMBL400402 | US8481536, 597 | US8481536, 449 | 4...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50221566(CHEMBL400402 | US8481536, 597 | US8481536, 449 | 4...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221566(CHEMBL400402 | US8481536, 597 | US8481536, 449 | 4...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed