BDBM50221553 4-(7-(2-chloro-5-hydroxyphenyl)-5-methylbenzo[e][1,2,4]triazin-3-ylamino)-N-(2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide::4-{[7-(2-chloro-5-hydroxyphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino}-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamide::CHEMBL249821::US8481536, 463::US8481536, 603

SMILES Cc1cc(cc2nnc(Nc3ccc(cc3)S(=O)(=O)NCCN3CCCC3)nc12)-c1cc(O)ccc1Cl

InChI Key InChIKey=ZBRROTSBDAODQD-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50221553   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50221553(US8481536, 603 | CHEMBL249821 | US8481536, 463 | 4...)
Affinity DataIC50: 3.60nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
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TargetTyrosine-protein kinase Yes(Human)
Targegen

US Patent
LigandPNGBDBM50221553(US8481536, 603 | CHEMBL249821 | US8481536, 463 | 4...)
Affinity DataIC50: 1.28nMT: 2°CAssay Description:Recombinant human c-Src or Yes (28 ng/well, Panvera/Invitrogen, Madison Wis.), ATP (3 μM), a tyrosine kinase substrate (PTK2, 250 μM, Promega C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Targegen

US Patent
LigandPNGBDBM50221553(US8481536, 603 | CHEMBL249821 | US8481536, 463 | 4...)
Affinity DataIC50: 1.70nMAssay Description:Pdgfrβ (0.16 ug/well, Panvera/Invitrogen) 500 nM ATP and the PTK2 peptide (700 uM) were combined with compound and reaction buffer as noted abov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
Go to US Patent

TargetEphrin type-B receptor 4(Human)
Targegen

US Patent
LigandPNGBDBM50221553(US8481536, 603 | CHEMBL249821 | US8481536, 463 | 4...)
Affinity DataIC50: 30.8nMT: 2°CAssay Description:EphB4 kinase activity was similarly measured, using the luciferase-based technique described above. 28.9 mU/well EphB4 (Upstate) was reacted with 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Targegen

US Patent
LigandPNGBDBM50221553(US8481536, 603 | CHEMBL249821 | US8481536, 463 | 4...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50221553(US8481536, 603 | CHEMBL249821 | US8481536, 463 | 4...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Targegen

US Patent
LigandPNGBDBM50221553(US8481536, 603 | CHEMBL249821 | US8481536, 463 | 4...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of YESMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Targegen

Curated by ChEMBL
LigandPNGBDBM50221553(US8481536, 603 | CHEMBL249821 | US8481536, 463 | 4...)
Affinity DataKi:  3nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed