BDBM50155926 CHEMBL3183703

SMILES CC(C)(c1cc(oc1)S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)O

InChI Key InChIKey=HUUSXLKCTQDPGL-UHFFFAOYSA-N

Data  30 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50155926   

TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated mouse BMDM cells assessed as inhibition of LPS and nigericin-induced IL-1beta pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of NLRP3 in human whole blood assessed as inhibition of IL-1beta production pretreated with LPS for 3 hrs followed by incubation with comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 60nMAssay Description:Inhibition of NLRP3 in LPS/nigericin-induced human THP-1 cells assessed as inhibition of IL-1beta production pretreated with LPS for 3 hrs followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 13nMAssay Description:Inhibition of NLRP3 inflammasome in mouse JJ74.A1 cells assessed as inhibition of LPS/ATP-induced IL-1 beta release stimulated with LPS for 4.5 hs fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 14nMAssay Description:Inhibition of NLRP3 inflammasome in mouse JJ74.A1 cells assessed as inhibition of LPS/ATP-induced IL-1 beta secretion primed with LPS for 4.5 hs foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 3.93E+3nMAssay Description:Inhibition of NLRP3 in LPS induced mouse BV-2 cells assessed as reduction in IL-1beta production pretreated for 30 mins followed by nigericin additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 28nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-induced human THP-1 cells expressing GFP-tagged ASC assessed as disruption of ASC speck formation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in human whole blood assessed as inhibition of LPS/ATP induced IL-1beta secretion preincubated with LPS f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 30nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-activated human PBMC cells assessed as inhibition of ATP/nigericin induced IL-1beta secretion prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataKd:  38nMAssay Description:Binding affinity to human recombinant NLRP3 (1 to 1036 residues) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse BMDM cells assessed as reduction in ATP induced IL-1beta release pretreated for 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 29nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and nigericin-stimulated human PBMC cells assessed as reduction in IL-1beta release preincubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 13nMAssay Description:Inhibition of NLRP3 inflammasome activation in PMA differentiated LPS-primed human THP-1 cells assessed as reduction in nigericin-induced IL-1beta le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 23nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated mouse J774A.1 cells assessed as decrease in IL-1beta level pretreated for 0.5 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 23nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated mouse J774A.1 cells assessed as decrease in LDH release pretreated for 0.5 hrs f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 22nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of NLRP3 in mouse BMDM cells preincubated for 30 mins followed by ATP addition by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2017
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 8nMAssay Description:Inhibition of NLRP3 in human THP1 cells assessed as inhibition of IL-1beta productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of NLRP3 in human monocyte-derived macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of NLRP3 in mouse BMDMsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed human monocyte derived macrophages assessed as reduction in IL-1beta level preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse bone marrow derived macrophages assessed as reduction in IL-1beta level preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 8nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in IL-1beta level preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
School of Pharmaceutical Sciences & The Fifth Affiliated Hospital

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by high throughput automated patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 40nMAssay Description:Inhibition of NLRP3 in mouse peritoneal macrophages assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 40nMAssay Description:Inhibition of NLRP3 in mouse peritoneal macrophages assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of NLRP3 in LPS/ATP-treated human monocyte derived macrophages assessed as reduction in NLRP3 inflammasome activation by measuring reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of NLRP3 in LPS/ATP-treated mouse bone marrow derived macrophages assessed as reduction in NLRP3 inflammasome activation by measuring redu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 8nMAssay Description:Inhibition of NLRP3 in human monocyte derived macrophages assessed as reduction in LPS-induced IL-1beta production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 5nMAssay Description:Inhibition of NLRP3 in human monocyte derived macrophages assessed as reduction in LPS-induced IL-1beta production incubated for 30 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50155926(CHEMBL3183703)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse BMDM assessed as reduction in NLRP3 inflammasome-induced IL-1beta production prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed