BDBM50106307 2-Phenyl-2,3-dihydro-1H-quinazolin-4-one::CHEMBL129312

SMILES O=C1NC(Nc2ccccc12)c1ccccc1

InChI Key InChIKey=BIVGFFFLVZMILM-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50106307   

TargetTubulin alpha-1A chain(Pig)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50106307(2-Phenyl-2,3-dihydro-1H-quinazolin-4-one | CHEMBL1...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of tubulin polymerization. (ITP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50106307(2-Phenyl-2,3-dihydro-1H-quinazolin-4-one | CHEMBL1...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50106307(2-Phenyl-2,3-dihydro-1H-quinazolin-4-one | CHEMBL1...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetCathepsin H(Goat)
Kurukshetra University

LigandPNGBDBM50106307(2-Phenyl-2,3-dihydro-1H-quinazolin-4-one | CHEMBL1...)
Affinity DataKi:  1.44E+4nMpH: 6.0Assay Description:Cathepsin B and H were first activated in the presence of thiol activators at pH 6.0 and pH 7.0, respectively. Then, 15 µL of the enzyme solution was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2015
Entry Details Article
PubMed
TargetCathepsin B(Goat)
Kurukshetra University

LigandPNGBDBM50106307(2-Phenyl-2,3-dihydro-1H-quinazolin-4-one | CHEMBL1...)
Affinity DataKi:  1.11E+5nMpH: 6.0Assay Description:Cathepsin B and H were first activated in the presence of thiol activators at pH 6.0 and pH 7.0, respectively. Then, 15 µL of the enzyme solution was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2015
Entry Details Article
PubMed