BDBM50059190 CHEMBL3393333::US20250032489, Compound GNE-3511

SMILES c1cnc(cc1C#N)Nc2cc(cc(n2)N3CCC(C3)(F)F)C4CCN(CC4)C5COC5

InChI Key InChIKey=RHFIAUKMKYHHFA-UHFFFAOYSA-N

Data  2 KI  11 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50059190   

LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataIC50: 30nMAssay Description:Inhibition of human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MKK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MKK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataIC50: 129nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataIC50: 514nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataIC50: 364nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataIC50: 68nMAssay Description:Inhibition of MLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataIC50: 767nMAssay Description:Inhibition of MLK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataIC50: 602nMAssay Description:Inhibition of MLK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataIC50: 3nMAssay Description:Inhibition of DLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 13(Human)
Denali Therapeutics

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataIC50: 3nMAssay Description:Inhibition of LZK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 13(Human)
Denali Therapeutics

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataKd:  3.20nMAssay Description:One hundred nanograms of glutathione S-transferase (GST)-tagged human LZK pure protein (Carna Biosciences, #09-114) was incubated with 100 ng of GST-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetProtein delta homolog 1(Human)
Department of Health And Human Services

US Patent
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataKd:  1.10nMAssay Description:One hundred nanograms of glutathione S-transferase (GST)-tagged human LZK pure protein (Carna Biosciences, #09-114) was incubated with 100 ng of GST-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent

LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataKi: <0.5nMAssay Description:Inhibition of DLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein delta homolog 1(Human)
Department of Health And Human Services

US Patent
LigandPNGBDBM50059190(CHEMBL3393333 | US20250032489, Compound GNE-3511)
Affinity DataKi: <0.5nMAssay Description:Binding affinity to DLK (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed