BDBM50031317 CHEMBL3358015

SMILES OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12

InChI Key InChIKey=LJWMTSMUQJNHOC-UHFFFAOYSA-N

Data  8 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50031317   

TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataKd:  1.09E+3nMAssay Description:Binding affinity to N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 3.71E+4nMAssay Description:Inhibition of PRMT1 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of SET7/9 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of MLL1 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of SUV39H1 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of G9a (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 3B(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of DNMT3B (unknown origin) incubated for 15 mins before addition of [3H]-SAM and poly(dI-dC).poly(dI-dC) by liquid scintillation counting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of DNMT3A (unknown origin) incubated for 15 mins before addition of [3H]-SAM and poly(dI-dC).poly(dI-dC) by liquid scintillation counting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed