BDBM4864 8-(4-Chloroanilino)-5-(4-pyridylmethyl)pyrido[2,3-d]-pyridazine::CGP79787 Analog 47::CHEMBL306284::N-(4-chlorophenyl)-5-(pyridin-4-ylmethyl)pyrido[2,3-d]pyridazin-8-amine

SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3cccnc23)cc1

InChI Key InChIKey=PAIOGTBZFHOIGA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4864   

TargetVascular endothelial growth factor receptor 1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM4864(N-(4-chlorophenyl)-5-(pyridin-4-ylmethyl)pyrido[2,...)
Affinity DataIC50: 1.70E+3nMpH: 7.5 T: 2°CAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Pharmaceuticals

LigandPNGBDBM4864(N-(4-chlorophenyl)-5-(pyridin-4-ylmethyl)pyrido[2,...)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Pharmaceuticals

LigandPNGBDBM4864(N-(4-chlorophenyl)-5-(pyridin-4-ylmethyl)pyrido[2,...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed