BDBM473962 4-(6,6-Dimethyl-7-oxo- 4,5,6,7-tetrahydro- benzoimidazol-1-yl)- benzonitrile::US10858342, Compound C-ADX

SMILES CC1(C)CCc2ncn(c2C1=O)-c1ccc(cc1)C#N

InChI Key InChIKey=VPELIWVFAVTUAI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 473962   

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473962(4-(6,6-Dimethyl-7-oxo- 4,5,6,7-tetrahydro- benzoim...)
Affinity DataIC50: 14nMAssay Description:Assays are performed in 96-well format in a final volume of 60 microL/well, containing 100 mM potassium phosphate, pH 7.4, 1% (v/v) DMSO, and additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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TargetCytochrome P450 11B1, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473962(4-(6,6-Dimethyl-7-oxo- 4,5,6,7-tetrahydro- benzoim...)
Affinity DataIC50: 2.14E+6nMAssay Description:Assays are performed as for aldosterone synthase except for the use of 150 units of CYP11B1, 11-deoxycortisol as substrate and cortisol measured as p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent