BDBM473948 3-(1,2,3,4-Tetrahydro- naphthalen-2-yl)-3,5,6,7- tetrahydro-benzoimidazol-4- one::US10858342, Compound C-ADJ

SMILES O=C1CCCc2ncn(C3CCc4ccccc4C3)c12

InChI Key InChIKey=GEDQQIISRRMWRF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 473948   

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473948(3-(1,2,3,4-Tetrahydro- naphthalen-2-yl)-3,5,6,7- t...)
Affinity DataIC50: 2.80nMAssay Description:Assays are performed in 96-well format in a final volume of 60 microL/well, containing 100 mM potassium phosphate, pH 7.4, 1% (v/v) DMSO, and additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473948(3-(1,2,3,4-Tetrahydro- naphthalen-2-yl)-3,5,6,7- t...)
Affinity DataIC50: 1.20E+6nMAssay Description:Assays are performed as for aldosterone synthase except for the use of 150 units of CYP11B1, 11-deoxycortisol as substrate and cortisol measured as p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent