BDBM473919 3-(4-Chloroophenyl)-6,6- spirocyclopropyl-3,5,6,7- tetrahydro-benzimidazolo- 4-one::US10858342, Compound C-ACF

SMILES Clc1ccc(cc1)-n1cnc2CC3(CCC3)CC(=O)c12

InChI Key InChIKey=MURDQCRGXVFGOI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 473919   

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473919(3-(4-Chloroophenyl)-6,6- spirocyclopropyl-3,5,6,7-...)
Affinity DataIC50: 10nMAssay Description:Assays are performed in 96-well format in a final volume of 60 microL/well, containing 100 mM potassium phosphate, pH 7.4, 1% (v/v) DMSO, and additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473919(3-(4-Chloroophenyl)-6,6- spirocyclopropyl-3,5,6,7-...)
Affinity DataIC50: 5.90E+5nMAssay Description:Assays are performed as for aldosterone synthase except for the use of 150 units of CYP11B1, 11-deoxycortisol as substrate and cortisol measured as p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent