BDBM473918 3-(3,4-Difluoro-phenyl)-6,6- spirocyclopropyl-3,5,6,7- tetrahydro-benzimidazolo-4- one::US10858342, Compound C-ACE

SMILES Fc1ccc(cc1F)-n1cnc2CC3(CCC3)CC(=O)c12

InChI Key InChIKey=AZCMGDISRIOEGC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 473918   

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473918(3-(3,4-Difluoro-phenyl)-6,6- spirocyclopropyl-3,5,...)
Affinity DataIC50: 20nMAssay Description:Assays are performed in 96-well format in a final volume of 60 microL/well, containing 100 mM potassium phosphate, pH 7.4, 1% (v/v) DMSO, and additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
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TargetCytochrome P450 11B1, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473918(3-(3,4-Difluoro-phenyl)-6,6- spirocyclopropyl-3,5,...)
Affinity DataIC50: 6.30E+5nMAssay Description:Assays are performed as for aldosterone synthase except for the use of 150 units of CYP11B1, 11-deoxycortisol as substrate and cortisol measured as p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent