BDBM473900 3-(4-Chloro-3-fluoro- phenyl)-6,6-dimethyl- 3,5,6,7-tetrahydro- benzoimidazol-4-one::US10858342, Compound C-ABM

SMILES CC1(C)Cc2ncn(c2C(=O)C1)-c1ccc(Cl)c(F)c1

InChI Key InChIKey=YIPVHBVXUWEDHN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 473900   

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473900(3-(4-Chloro-3-fluoro- phenyl)-6,6-dimethyl- 3,5,6,...)
Affinity DataIC50: 4.70nMAssay Description:Assays are performed in 96-well format in a final volume of 60 microL/well, containing 100 mM potassium phosphate, pH 7.4, 1% (v/v) DMSO, and additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473900(3-(4-Chloro-3-fluoro- phenyl)-6,6-dimethyl- 3,5,6,...)
Affinity DataIC50: 7.70E+5nMAssay Description:Assays are performed as for aldosterone synthase except for the use of 150 units of CYP11B1, 11-deoxycortisol as substrate and cortisol measured as p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent