BDBM445059 US10669227, Compound 5::US11608309, Compound 5

SMILES C[NH2+]Cc1ccc(\C=C\C(=O)CC(=O)\C=C\c2ccc(cc2)[NH+](C)C)cc1

InChI Key InChIKey=BGDSIMSIIUZPPX-UHFFFAOYSA-P

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 445059   

TargetNeutrophil collagenase(Human)
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM445059(US10669227, Compound 5 | US11608309, Compound 5)
Affinity DataIC50: 2.80E+4nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
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TargetNeutrophil collagenase(Human)
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM445059(US10669227, Compound 5 | US11608309, Compound 5)
Affinity DataIC50: 2.80E+4nMAssay Description:Table 1 shows the IC50 of curcumin, compound 1, and compound 2, compared to a standard Zn++ binding & MMPI (matrix metalloproteinase inhibitor), 1,10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent