BDBM423180 N-[(5R)-1-Amino-3-methyl-5H,6H,7H-cyclopenta[c]pyridin-5-yl]-1-[(6-{6,6-difluoro-3-azabicyclo[3.1.0]hexan-3-yl}-2-methylpyridin-3-yl)methyl]-1H-pyrazole-4-carboxamide::US10501440, Example 10

SMILES Cc1cc2[C@@H](CCc2c(N)n1)NC(=O)c1cnn(Cc2ccc(nc2C)N2CC3C(C2)C3(F)F)c1

InChI Key InChIKey=RBEJFEBBRUQTOB-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 423180   

TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423180(US10501440, Example 10 | N-[(5R)-1-Amino-3-methyl-...)
Affinity DataIC50: 0.400nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423180(US10501440, Example 10 | N-[(5R)-1-Amino-3-methyl-...)
Affinity DataKi:  0.400nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent