BDBM423176 US10501440, Example 7

SMILES Cc1nc(ccc1Cn1cc(C(=O)N[C@@H]2CCc3c2ccnc3N)c(n1)C(F)(F)F)N1CC2C(C1)C2(F)F

InChI Key InChIKey=QLCURGKHEDHWIR-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 423176   

TargetPlasma kallikrein(Rat)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423176(US10501440, Example 7)
Affinity DataIC50: 1.10nMAssay Description:Human KLKB1 (0.01 U/mL; Enzyme Research Laboratories) or rat KLKB1 (0.625 nM; produced in-house) was incubated for 1 h at room temperature with 0.10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
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TargetPlasma kallikrein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM423176(US10501440, Example 7)
Affinity DataKi:  1.90nMAssay Description:Human KLKB1 (1.78 nM or 0.025 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent