BDBM340031 1-{3-fluoro-4-[7-(5-methyl-1H-imidazol-2- yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]- phenyl}-3-(2,4,6-trifluoro-phenyl)-urea::US10604508, Compound 7::US11230539, Compound 7::US9758508, Compound 7

SMILES Cc1cnc([nH]1)-c1ccc(c2CNC(=O)c12)-c1ccc(NC(=O)Nc2c(F)cc(F)cc2F)cc1F

InChI Key InChIKey=MWHHJYUHCZWSLS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 340031   

TargetTyrosine-protein kinase BTK(Human)
Crystalgenomics

US Patent
LigandPNGBDBM340031(US9758508, Compound 7 | 1-{3-fluoro-4-[7-(5-methyl...)
Affinity DataIC50: 0.100nMAssay Description:In order to evaluate the activity of the compounds of the present invention as a BTK inhibitor, commercially available BTK (Promega) was used for thi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Crystalgenomics

US Patent
LigandPNGBDBM340031(US9758508, Compound 7 | 1-{3-fluoro-4-[7-(5-methyl...)
Affinity DataIC50: 0.100nMAssay Description:In order to evaluate the activity of the compounds of the present invention as a BTK inhibitor, commercially available BTK (Promega) was used for thi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Crystalgenomics

US Patent
LigandPNGBDBM340031(US9758508, Compound 7 | 1-{3-fluoro-4-[7-(5-methyl...)
Affinity DataIC50: 0.100nMAssay Description:In order to evaluate the activity of the compounds of the present invention as a BTK inhibitor, commercially available BTK (Promega) was used for thi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2022
Entry Details
Go to US Patent