BDBM340030 1-(2-chloro-6-fluoro-phenyl)-3-{3-fluoro-4- [7-(5-methyl-1H-imidazol-2-yl)-1-oxo-2,3- dihydro-1H-isoindol-4-yl]-phenyl}-urea::US10604508, Compound 4::US11230539, Compound 4::US9758508, Compound 4

SMILES Cc1cnc([nH]1)-c1ccc(c2CNC(=O)c12)-c1ccc(NC(=O)Nc2c(F)cccc2Cl)cc1F

InChI Key InChIKey=RFJQQPNGJAELNV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 340030   

TargetTyrosine-protein kinase BTK(Human)
Crystalgenomics

US Patent
LigandPNGBDBM340030(US9758508, Compound 4 | 1-(2-chloro-6-fluoro-pheny...)
Affinity DataIC50: 0.900nMAssay Description:In order to evaluate the activity of the compounds of the present invention as a BTK inhibitor, commercially available BTK (Promega) was used for thi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Crystalgenomics

US Patent
LigandPNGBDBM340030(US9758508, Compound 4 | 1-(2-chloro-6-fluoro-pheny...)
Affinity DataIC50: 0.900nMAssay Description:In order to evaluate the activity of the compounds of the present invention as a BTK inhibitor, commercially available BTK (Promega) was used for thi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Crystalgenomics

US Patent
LigandPNGBDBM340030(US9758508, Compound 4 | 1-(2-chloro-6-fluoro-pheny...)
Affinity DataIC50: 0.900nMAssay Description:In order to evaluate the activity of the compounds of the present invention as a BTK inhibitor, commercially available BTK (Promega) was used for thi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2022
Entry Details
Go to US Patent