BDBM25195 4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}phenol::6-substituted 4-anilinoquinoline, 35

SMILES Cc1ccc(O)cc1Nc1ccnc2ccc(cc12)-c1cccnc1

InChI Key InChIKey=BYVUAJDYENVNAV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 25195   

LigandPNGBDBM25195(4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}p...)
Affinity DataIC50: 80nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2008
Entry Details Article
PubMed
LigandPNGBDBM25195(4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}p...)
Affinity DataIC50: 10nMAssay Description:Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM25195(4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}p...)
Affinity DataIC50: 3.74E+3nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM25195(4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}p...)
Affinity DataIC50: 460nMAssay Description:Inhibition of VEGFR2(unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMed