BDBM24694 4-aminopyrazolylpyrimidine analogue, 5::5-bromo-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine

SMILES Cc1cc(CNc2ncc(Br)c(Nc3cc(n[nH]3)C3CC3)n2)on1

InChI Key InChIKey=MJQVDJSEAMOVCO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24694   

TargetBDNF/NT-3 growth factors receptor(Human)
Astrazeneca

LigandPNGBDBM24694(5-bromo-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-[(...)
Affinity DataIC50: 1.10E+3nMpH: 7.4 T: 2°CAssay Description:TrkB kinase activity was measured against its ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substrate using homog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed
LigandPNGBDBM24694(5-bromo-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-[(...)
Affinity DataIC50: 270nMpH: 7.4 T: 2°CAssay Description:TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed