BDBM23996 5-ethyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,2'-[1,3,4]thiadiazole]-2-one::US12194027, Compound OGM2::thiadiazole derivative, 11

SMILES CCc1ccc2NC(=O)C3(NN=C(S3)c3ccccc3)c2c1

InChI Key InChIKey=ICJWVAKZQXYHBB-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 23996   

LigandPNGBDBM23996(5-ethyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,2...)
Affinity DataIC50: 9.60E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetOvarian cancer G-protein coupled receptor 1(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM23996(5-ethyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,2...)
Affinity DataEC50:  1.35E+3nMAssay Description:Briefly, the methods were: On the day before the assay 20,000 cells per well of CHEM1-OGR1 cells were plated in 10% DMEM containing 10% FBS and 1% Pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetOvarian cancer G-protein coupled receptor 1(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM23996(5-ethyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,2...)
Affinity DataIC50: 710nMAssay Description:Briefly, the methods were: On the day before the assay 20,000 cells per well of CHEM1-OGR1 cells were plated in 10% DMEM containing 10% FBS and 1% Pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent