BDBM23995 5-methyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,2'-[1,3,4]thiadiazole]-2-one::US12194027, Compound OGM3::thiadiazole derivative, 10

SMILES Cc1ccc2NC(=O)C3(NN=C(S3)c3ccccc3)c2c1

InChI Key InChIKey=FREUDXYIZICEHS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 23995   

LigandPNGBDBM23995(5-methyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,...)
Affinity DataIC50: 1.11E+4nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2008
Entry Details Article
PubMed
TargetOvarian cancer G-protein coupled receptor 1(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM23995(5-methyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,...)
Affinity DataIC50: 760nMAssay Description:Briefly, the methods were: On the day before the assay 20,000 cells per well of CHEM1-OGR1 cells were plated in 10% DMEM containing 10% FBS and 1% Pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetLysophosphatidic acid receptor 1(Human)
University of Maryland, Baltimore

US Patent
LigandPNGBDBM23995(5-methyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,...)
Affinity DataIC50: 6.40E+3nMAssay Description:Briefly, the methods were: On the day before the assay 20,000 cells per well of CHEM1-OGR1 cells were plated in 10% DMEM containing 10% FBS and 1% Pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent