BDBM200712 US9233086, 10A

SMILES CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccccc1)c1ccccc1

InChI Key InChIKey=BCIPILGGOSCOMC-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 200712   

TargetWD repeat-containing protein 5 [24-334](Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataIC50: 1.00E+3nMpH: 6.5 T: 2°CAssay Description:All the FP based experiments were performed in MICROFLUOR 2 Black, "U" Bottom, 96-well Microtiter Plates (ThermoSci.) and FP was measured as mP units...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
Go to US Patent

TargetWD repeat-containing protein 5(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of N-terminal His-tagged WDR5 (24 to 334 residues) (unknown origin) interaction with MLL1 assessed as displacement of 5-Lys-FAM peptide su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2017
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetWD repeat-containing protein 5(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataIC50: 2.90nMAssay Description:Displacement of fluorescence-labelled Ac-ARA peptide from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetWD repeat-containing protein 5(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataIC50: 2.90nMAssay Description:Binding affinity to WDR5 (unknown origin) fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataKi: <1nMAssay Description:Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetWD repeat-containing protein 5(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataKi: <1nMAssay Description:Displacement of 5-FAM labelled tracer from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed