BDBM150781 2-(4-Methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (1d)

SMILES COc1ccc(cc1)C1NC(=O)c2ccccc2N1

InChI Key InChIKey=YYTAMNASXHFOKH-UHFFFAOYSA-N

Data  3 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 150781   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM150781(2-(4-Methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-on...)
Affinity DataIC50: 990nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM150781(2-(4-Methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-on...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
China Medical College

Curated by ChEMBL
LigandPNGBDBM150781(2-(4-Methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-on...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM150781(2-(4-Methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-on...)
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of Saccharomyces cerevisiae alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM150781(2-(4-Methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-on...)
Affinity DataKi:  420nMAssay Description:Inhibition of Saccharomyces cerevisiae alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate assessed as inhibition constant pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCathepsin B(Goat)
Kurukshetra University

LigandPNGBDBM150781(2-(4-Methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-on...)
Affinity DataKi:  2.81E+3nMpH: 6.0Assay Description:Cathepsin B and H were first activated in the presence of thiol activators at pH 6.0 and pH 7.0, respectively. Then, 15 µL of the enzyme solution was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2015
Entry Details Article
PubMed
TargetCathepsin H(Goat)
Kurukshetra University

LigandPNGBDBM150781(2-(4-Methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-on...)
Affinity DataKi:  5.68E+4nMpH: 6.0Assay Description:Cathepsin B and H were first activated in the presence of thiol activators at pH 6.0 and pH 7.0, respectively. Then, 15 µL of the enzyme solution was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2015
Entry Details Article
PubMed