BDBM150780 2-(4-Methylphenyl)-2,3-dihydroquinazolin-4(1H)-one (1c)

SMILES Cc1ccc(cc1)C1NC(=O)c2ccccc2N1

InChI Key InChIKey=ZRJPAELTYZGKSY-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 150780   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM150780(2-(4-Methylphenyl)-2,3-dihydroquinazolin-4(1H)-one...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM150780(2-(4-Methylphenyl)-2,3-dihydroquinazolin-4(1H)-one...)
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2016
Entry Details Article
PubMed
TargetCathepsin H(Goat)
Kurukshetra University

LigandPNGBDBM150780(2-(4-Methylphenyl)-2,3-dihydroquinazolin-4(1H)-one...)
Affinity DataKi:  2.50E+3nMpH: 6.0Assay Description:Cathepsin B and H were first activated in the presence of thiol activators at pH 6.0 and pH 7.0, respectively. Then, 15 µL of the enzyme solution was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2015
Entry Details Article
PubMed
TargetCathepsin B(Goat)
Kurukshetra University

LigandPNGBDBM150780(2-(4-Methylphenyl)-2,3-dihydroquinazolin-4(1H)-one...)
Affinity DataKi:  5.26E+4nMpH: 6.0Assay Description:Cathepsin B and H were first activated in the presence of thiol activators at pH 6.0 and pH 7.0, respectively. Then, 15 µL of the enzyme solution was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2015
Entry Details Article
PubMed