BDBM14824 4-({5-bromo-4-[(4-methoxyphenyl)amino]pyrimidin-2-yl}amino)benzoic acid::AstraZeneca compound 1::JMC514672 Compound 30

SMILES COc1ccc(Nc2nc(Nc3ccc(cc3)C(O)=O)ncc2Br)cc1

InChI Key InChIKey=YMPWYIHAVYUJEK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14824   

TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

LigandPNGBDBM14824(JMC514672 Compound 30 | 4-({5-bromo-4-[(4-methoxyp...)
Affinity DataIC50: 450nMpH: 7.5 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified recombinant Chk1 and biotinylated peptide substrate in the presence ATP/[...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2007
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Astrazeneca

LigandPNGBDBM14824(JMC514672 Compound 30 | 4-({5-bromo-4-[(4-methoxyp...)
Affinity DataIC50: 646nMpH: 7.4 T: 2°CAssay Description:TrkB kinase activity was measured against its ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substrate using homog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2008
Entry Details Article
PubMed