BDBM50076273 (2R,3R)-2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acryloyloxy]-succinic acid::1-chicoricacid::CHEMBL282731::Cichoric acid (CHA)::HIV-1 Integrase Inhibitor::L-chicoric acid::cichoric acid

SMILES c1c(cc(c(c1)O)O)/C=C/C(=O)O[C@@H](C(=O)O)[C@@H](OC(=O)/C=C/c2cc(c(cc2)O)O)C(=O)O

InChI Key InChIKey=YDDGKXBLOXEEMN-UHFFFAOYSA-N

Data  3 KI  8 IC50  2 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50076273   

LigandPNGBDBM50076273(Cichoric acid (CHA) | HIV-1 Integrase Inhibitor | ...)
Affinity DataKd:  1.60E+6nMAssay Description:NMR chemical shift perturbations of PTP1B resonances due to binding of CHA and CGA were monitored by acquiring a series of 1H−15N TROSY spectra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50076273(Cichoric acid (CHA) | HIV-1 Integrase Inhibitor | ...)
Affinity DataIC50: 1.37E+4nMAssay Description:Inhibitory activity against HIV-1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50076273(Cichoric acid (CHA) | HIV-1 Integrase Inhibitor | ...)
Affinity DataIC50: 800nMAssay Description:Inhibition of HIV-1 integrase by radiolabeled oligonucleotide-based assay integrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50076273(Cichoric acid (CHA) | HIV-1 Integrase Inhibitor | ...)
Affinity DataIC50: 1.10E+3nMAssay Description:Compound was evaluated for the inhibitory concentration against HIV-1 integrase by radiolabeled oligonucleotide-based assay 3''-processingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50076273(Cichoric acid (CHA) | HIV-1 Integrase Inhibitor | ...)
Affinity DataIC50: 2.49E+4nMAssay Description:Inhibitory activity against HIV-1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Institute of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50076273(Cichoric acid (CHA) | HIV-1 Integrase Inhibitor | ...)
Affinity DataKd:  3.00E+3nMAssay Description:Kd value against HIV-1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Rhodes University

Curated by ChEMBL
LigandPNGBDBM50076273(Cichoric acid (CHA) | HIV-1 Integrase Inhibitor | ...)
Affinity DataIC50: 34nMAssay Description:Inhibition of HIV-1 subtype C integrase in presence of biotinylated DNA by colorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Rhodes University

Curated by ChEMBL
LigandPNGBDBM50076273(Cichoric acid (CHA) | HIV-1 Integrase Inhibitor | ...)
Affinity DataIC50: 200nMAssay Description:Inhibition of HIV1 integrase using U5A/U5B double-stranded DNA as substrate by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Rhodes University

Curated by ChEMBL
LigandPNGBDBM50076273(Cichoric acid (CHA) | HIV-1 Integrase Inhibitor | ...)
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of HIV1 recombinant integrase expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase YopH(Yersinia enterocolitica)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50076273(Cichoric acid (CHA) | HIV-1 Integrase Inhibitor | ...)
Affinity DataIC50: 3.79E+5nMAssay Description:Inhibition of recombinant Yersinia enterocolitica YopH assessed as reduction in conversion of pNPP to nitrophenol and inorganic phosphate using pNPP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase YopH(Yersinia enterocolitica)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50076273(Cichoric acid (CHA) | HIV-1 Integrase Inhibitor | ...)
Affinity DataKi:  1.25E+4nMAssay Description:Non-competitive mixed inhibition of Yersinia enterocolitica YopH assessed as inhibition constant for enzyme-substrate complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase YopH(Yersinia enterocolitica)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50076273(Cichoric acid (CHA) | HIV-1 Integrase Inhibitor | ...)
Affinity DataKi:  6.83E+4nMAssay Description:Non-competitive mixed inhibition of Yersinia enterocolitica YopH assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50076273(Cichoric acid (CHA) | HIV-1 Integrase Inhibitor | ...)
Affinity DataKi:  1.40E+6nMAssay Description:Steady-state kinetic parameters were measured for PTP1B using p-nitrophenyl phosphate (pNPP, 0.5−40 mM) as the substrate in NMR buffer. The rat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed