54 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
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Article Title
Organization
Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.
University of Toronto
Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents.
University of Toronto
Radiosynthesis and ex vivo evaluation of [(18)F]-(S)-3-(6-(3-fluoropropoxy)benzo[d]isoxazol-3-yl)-5-(methoxymethyl)oxazolidin-2-one for imaging MAO-B with PET.
University of Toronto
Total synthesis and antibacterial testing of the A54556 cyclic acyldepsipeptides isolated from Streptomyces hawaiiensis.
University of Toronto
A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells.
University of Toronto
Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
University of Toronto
Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation.
University of Toronto
Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics.
University of Toronto
Naphthalenebis[alpha,alpha-difluoromethylenephosphonates] as potent inhibitors of protein tyrosine phosphatases.
University of Toronto
Synthesis and in vitro evaluation of derivatives of theß¿?-adrenergic receptor antagonist HX-CH 44.
University of Toronto
Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein.
University of Toronto
A collection of caged compounds for probing roles of local translation in neurobiology.
University of Toronto
Discovery of mu-opioid selective ligands derived from 1-aminotetralin scaffolds made via metal-catalyzed ring-opening reactions.
University of Toronto
Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning.
University of Toronto
Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6.
University of Toronto
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex.
University of Toronto
Pharmacological Targeting of Executioner Proteins: Controlling Life and Death.
University of Toronto
Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases.
University of Toronto
Ferulic acid amide derivatives with varying inhibition of amyloid-β oligomerization and fibrillization.
University of Toronto
Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2.
University of Toronto
Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening.
University of Toronto
Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain.
University of Toronto
Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.
University of Toronto
Identification and characterization of the first fragment hits for SETDB1 Tudor domain.
University of Toronto
Novel phosphate mimetics for the design of non-peptidyl inhibitors of protein tyrosine phosphatases.
University of Toronto
De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX.
University of Toronto
The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein.
University of Toronto
Monosaccharide inhibitors targeting carbohydrate esterase family 4 de-N-acetylases.
University of Toronto
Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
University of Toronto
Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor.
University of Toronto
Noncovalent Protein Arginine Deiminase (PAD) Inhibitors Are Efficacious in Animal Models of Multiple Sclerosis.
University of Toronto
Use of small molecule inhibitors targeting EYA tyrosine phosphatase
Cincinnati Childrens Hospital Medical Center
Cloning, expression, and pharmacological characterization of a novel human histamine receptor.
Smithkline Beecham Pharmaceuticals
Characterization of [3H]RX821002 binding to alpha-2 adrenergic receptor subtypes.
University of Nebraska
Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity.
National Cancer Institute-Bethesda
New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C(8) Substitution in Structural Analogues of S-Adenosylmethionine (dagger).
Cornell University
Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.
Amgen
Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors.
University of Alberta
The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-alpha and IKK-beta kinases.
Gsk
Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications.
Pfizer
Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies.
Purdue University
Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
Incyte